Bioavailability of salbutamol.

Bioavailability of salbutamol.

1 Jenne JW, Siever JR, Druz WS, Solano JV, Cohen SM, Sharp JT. The effect ofmaintenance theophylline therapy on lung work in severe chronic obstructive pulmonary disease while standing and walking. Am Rev Respir Dis 1984;130: 600-5. 2 Chrystyn H, Mulley BA, Peake MD. Dose response relation to oral theophylline in severe chronic obstructive airways disease. BMJ 1988;297: 1506-10. 3 Noseda A, Sch...

Lung bioavailability of generic and innovator salbutamol metered dose inhalers.

BACKGROUND The aim of this study was to determine whether significant differences exist in lung bioavailability between generic (Salamol, Salbulin) and innovator (Ventolin) formulations of inhaled salbutamol given by metered dose inhalers. METHODS Ten healthy volunteers of mean age 20.5 years with a forced expiratory volume in one second (FEV1) of 112.1% predicted were studied in a randomised...

Bioavailability assessment of salbutamol sulfate suppositories in human volunteers.

The purpose of this investigation was to evaluate the bioavailability of three salbutamol sulfate suppository formulations. The formulations were; 2 mg salbutamol sulfate in Suppocire NA base containing 6% Eudispert gel (F1), 2mg salbutamol sulfate in Witepsol H15 base containing 3% methyl cellulose gel (F2), and 2 mg salbutamol sulfate in Witepsol W25 base containing 3% methyl cellulose gel (F...

Lung bioavailability of generic and innovator salbutamol MDIs.

The Bioavailability of Salbutamol in Urine via Volumatic and Nonvolumatic Valved Holding Chambers

PURPOSE Pressurized metered dose inhalers are commonly used in patients with asthma. However, the need to coordinate inhalation with inhaler actuation means that they are not suitable for use per se. Valved holding chamber devices were developed to overcome some of the problems of pressurized metered dose inhalers. Several types of holding chambers of different sizes are available in Iran. This...